Check out the Betway Insider's MLB predictions page for the best bets throughout the 2021 season. 

Toronto Blue Jays to beat Washington Nationals

The Blue Jays clawed their way back to .500 on the season with a 9-5 win over Washington on Tuesday, as Vladimir Guerrero batted in seven runs on three homers on a career-best night.

Steven Matz returns to the mound for Toronto on Wednesday, and the lefty has been lights out so far.

He is 4-0 through four starts with a 2.31 ERA, having allowed just one run on three of those appearances.

Starting for Washington is Erick Fedde, who is 1-2 on the season with a 5.51 ERA.

Matz should get the better of a Nationals offense that has scored the second-fewest runs in MLB so far this season.

Atlanta Braves to beat Chicago Cubs

The 11-12 Braves are yet to really get going this year but have won six of their last 10, including the first two games of this series.

It is hard to stop this Atlanta team when its offense gets going, and its big guns have shown signs of life during this four-game set with Chicago.

Freddie Freeman, Dansby Swanson and Ronald Acuna Jr. have all hit home runs against the Cubs, while Ozzie Albies also looks hot.

Huascar Ynoa will be on the mound for Atlanta on Wednesday. He is coming off his first win of the season against Arizona last week in which he allowed just two hits through six innings.

Starting for Chicago is Kyle Hendricks, who has made an uncertain start to the campaign with a 1-2 record and a 5.68 ERA.

He may struggle to contain a Braves offense that is heating up as they look to return to .500 on the season.

San Diego Padres to beat Arizona Diamondbacks

The Diamondbacks have been a surprise package over the past couple of weeks, with a 5-1 win in the series opener on Tuesday taking them above the Padres in the NL West.

Arizona will like its chances on Wednesday, too, with Taylor Widener on the mound. He is 1-0 through four starts, with that win coming against the Friars on April 4.

He makes up one half of what should be a brilliant pitching duel as Ryan Weathers gets the start for San Diego.

The impressive rookie is 1-0 through two starts having shut out his opponents on both occasions, including allowing just one hit through 5.2 innings against World Series favourites the Los Angeles Dodgers in his most recent outing.

Despite their loss on Tuesday, the Padres have been highly effective on the road this season, going 8-4 away from Petco Park.

Their offense is unlikely to be limited to just a single run again on Wednesday, and they should be given a good platform to work with by Weathers.

San Francisco Giants to beat Colorado Rockies

San Francisco is another team in the NL West that has been impressive so far, with its 15-9 record good enough to share the division lead with the slumping Dodgers.

The Giants lost the second game of the series in extra innings on Tuesday but won the opener 12-0. They are also 7-3 over their last 10 and 9-3 at Oracle Park this season.

Veteran lefty Alex Wood gets the start on Wednesday, having gone 2-0 through two starts this season with a 0.75 ERA.

His opposite number will be Colorado ace German Marquez, who owns a 1-1 record through five starts. Marquez has allowed at least five hits in four of those outings, and has a worrying strikeout-to-walk ratio of 1.75.

Expect a bounce-back performance from San Francisco on Wednesday, behind another stingy start for Wood.

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