Sassuolo to beat Catania (17:00)
Sassuolo hammered Serie C side Ternana 5-1 in the previous round of the Coppa Italia in August and should have no trouble dispatching another.
They have lost just once in eight at the Mapei Stadium this season and, despite drawing their last three home games, are worth backing.
Catania have lost their last five Coppa Italia matches against Serie A sides.
Lyon to beat Stade Rennes (18:00)
Lyon are unbeaten in their last nine matches in all competitions following their 2-2 draw with Manchester City with a two-goal comeback to earn a point at Lille.
Bruno Genesio’s side have dropped just four points in their last six Ligue 1 matches, with their last defeat coming against Paris Saint-Germain in October.
Rennes lost 4-1 at home to Strasbourg at the weekend and have beaten only struggling Caen and Monaco in their last 11 league games.
Stade Reims to beat Toulouse (18:00)
Reims come into this match on the back of a credible goalless draw away to Marseille and just one defeat in their last eight Ligue 1 matches.
They have won back-to-back home games against Guingamp and Monaco, who make up the current bottom two, and should have more joy against their out-of-form visitors.
Toulouse are currently bottom of the Ligue 1 form table, having failed to win any of their last 11 league games.
Real Sociedad to beat Celta Vigo (18:30)
Celta Vigo are without an away win in their last five matches, since beating Levante 2-1 in August.
They have managed just two victories in their last 12 games in all competitions, so there is plenty of reason to get behind their opponents.
Sociedad won 2-1 at home when the two sides last met two weeks ago and also held out for a 1-1 draw in the first leg of this tie last month.
Paris Saint-Germain (-1) to beat Strasbourg (20:00)
Paris Saint-Germain had won 14 league games out of 14 prior to their draw at Bordeaux last weekend.
Thomas Tuchel’s side had won all of their previous six away games in the league by two or more goals and should get back on track on Wednesday.
Strasbourg claimed their first win in five at the weekend and have failed to win any of their five matches against the current top six.
*Odds subject to change.
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