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Wales (-19.5)
Wales have won their last 15 matches against Italy, with four of their last five victories coming by 20 points or more.
There is little reason to think Saturday will not follow the same pattern. Wales have already won the Triple Crown. while Italy have lost each of their three matches by at least 23 points.
Over 53.5 points
Wales are the top scorers in the competition so far with 86, and should have little trouble adding significantly to that tally on Saturday.
Italy have shipped 50, 41 and 48 points in their three matches to date, and should be able to make up the difference should Wales fall short of this mark on their own.
Liam Williams to score anytime
Williams has scored a try in each of his two appearances in the 2021 Six Nations, and will line up at full-back again for Wales.
He has three tries in six previous starts against the Azzurri.
Justin Tipuric to score anytime
Tipuric is genuine try threat from the pack, having dotted down 10 times during his international career.
He has scored two tries in his last three matches against Italy, so looks a nice bet to score this weekend.
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