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Frankfurt to beat Mainz (17:30) –

Frankfurt lost 3-0 at Augsburg on Sunday, but should make amends on Wednesday.

That was the first defeat in seven in all competitions for Niko Kovac’s side, who remain in the top six of the Bundesliga and had won four of their previous six.

Mainz have lost back-to-back matches andare the second-worst travellers in the division, with just four points from 10 away games.

AZ Alkmaar to beat FC Twente (17:30) –

AZ Alkmaar were held to a 2-2 draw by second-bottom Roda last weekend, but have now lost just one in 14.

AZ are also unbeaten in nine league games away from home, with their only loss on the road coming against PSV on the opening day of the season.

Twente lost 1-0 to Heerenveen last weekend and have picked up just two points in their last five matches.

VVV Venlo to beat Willem II (19:45) –

VVV Venlo come into this match on the back of an impressive 1-0 win at home to defending champions Feyenoord.

That was their fourth victory in a five-game unbeaten run for Maurice Steijn’s side, who are a great price to continue their excellent form.

Willem II lost 1-0 at bottom-of-the-league Sparta Rotterdam on Sunday and are bottom of the Eredivisie form table, having taken just two points from their last six matches.

Lyon to win or draw v Montpellier (20:00) –

A 3-2 reversal at Monaco on Sunday made it two defeats in succession for Lyon, but they are capable of arresting their slide.

Bruno Genesio’s side, who had won six of their previous seven matches, have the second-best away record in Ligue 1, winning eight out of 13.

Montpellier have lost back-to-back away games, conceding six goals and failing to score in either, and have won just two in nine.

Sevilla to beat Leganes (20:30) –

Sevilla have won 11 and lost just one of their 17 matches at the Ramon Sanchez Pizjuan this season.

Los Rojiblancos also beat second-place Atletico Madrid in the previous round of the Copa del Rey, and should have no trouble in securing their place in the final.

Leganes were held to a 0-0 draw at Getafe on Sunday and have managed just one away victory in 10.

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*Odds subject to change.