James Wade and Peter Wright both need a win to keep their slim play-off hopes alive, with very little to choose between the two.
The pair are level on points, each have three wins in their last six matches and boast a near-identical checkout percentage over the tournament.
They also met over the weekend in a Pro Tour event where it went all the way to a deciding leg which Wade won.
Crucially, however, it is Wright – who won their meeting earlier in the Betway Premier League – with all the momentum at a critical time.
The Machine has only been able to register one point from his last four outings while Snakebite managed to take three off Phil Taylor and Gary Anderson last week, so expect the Scotsman to stay in contention no matter how briefly.
Gary Anderson can confirm his play-off spot with a win over Robert Thornton on Thursday.
The Flying Scotsman’s form has not been exceptional, with a narrow victory over Raymond van Barneveld his only win in his last five contests.
Thornton, though, has not proved to be a particularly testing opponent this year, with only two wins to date leaving him along way adrift in eighth.
The Thorn does have a decent record against his fellow countryman, but Anderson won earlier in this competition and there is little to suggest that he won’t do so again.
He may not be in peak form, but the world champion is still playing comfortably better than the Premier League’s poorest player.
Although Barney does tend to perform well against Michael van Gerwen, it has to look past the world No. 1 in this one.
MVG has been a bit up-and-down recently but was back to his sensational best last week, thumping Wade 7-1 with a 108 average to move level on points with Phil Taylor.
Van Barneveld, on the other hand, is out of the running for a semi-final spot after an uninspiring tournament.
He has registered some incredible wins over Mighty Mike – most recently at the World Championship in December – but Van Gerwen’s extra motivation should make all the difference here.
Phil Taylor lost for the first time since the opening night last week against Peter Wright, but still averaged well over 100 so will not be too concerned about that result.
The Power has been in scintillating form for quite some time and thrashed Lewis 7-1 in their earlier meeting in the tournament.
Jackpot has had an impressive Premier League so far and is still well placed to make the semis but he has not been great against the very best players, also losing twice to Michael van Gerwen.
The two-time world champion has beaten Taylor a couple of times already this year, but Phil is playing too well at the moment to be overcome again.
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