{"id":120425,"date":"2026-09-09T21:29:50","date_gmt":"2026-09-09T20:29:50","guid":{"rendered":"https:\/\/blog.betway.com\/?p=120425"},"modified":"2026-09-09T21:42:47","modified_gmt":"2026-09-09T20:42:47","slug":"rams-vs-49ers-picks-and-predictions-nfl-week-1-2026","status":"publish","type":"post","link":"https:\/\/blog.betway.com\/ca\/football\/nfl\/rams-vs-49ers-picks-and-predictions-nfl-week-1-2026\/","title":{"rendered":"Rams vs 49ers Picks &amp; Predictions | NFL Week 1 2026"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":0,"featured_media":120397,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[765],"tags":[],"class_list":["post-120425","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nfl"],"acf":{"brief_description":"Our Rams vs 49ers betting picks for NFL Week 1 2026 include odds analysis, best bets, key matchups and picks for your same game parlay","auto_update_sportal365":true,"property_type":["","run_ads","","","",""],"main_image":120398,"authors":false,"custom_author":"Mark Keast","type":"news","properties":{"ads_enabled":true,"adult_content":false,"important":false,"live":false},"live_url":"","type_of_redirect":"permanent","body":[{"acf_fc_layout":"editor_block","content":"<p>A regular-season NFL game in Australia is wild on its own, considering the league has never gone further than Europe and Mexico. But it shows how committed the NFL is to international expansion.<\/p>\n<p style=\"text-align: start;\">Somehow, for Thursday\u2019s San Francisco 49ers-L.A. Rams game, at Melbourne Cricket Ground, schedule makers slotted kickoff for 8:35 p.m. EST, broadcast on Netflix. That\u2019s 10:30 a.m. Friday, Australia time.<\/p>\n<p style=\"text-align: start;\">Divisional rivalry aside, travel, time zone adjustment, and preparation are the big factors.<\/p>\n<p style=\"text-align: start;\">Interesting \u2013 both teams took different tactics getting there, halfway around the world. The 49ers have been there a week already. The Rams arrive around 24 hours before kickoff, Australia time. Who will be fresher?<\/p>\n<p style=\"text-align: start;\">The big news on Tuesday was that star defensive tackle Aaron Donald, who came out of retirement Aug. 30 to rejoin the Rams, will not travel to Australia for the game. The team wants to give him more time to ramp up before he jumps back into the lineup after two seasons of retirement.<\/p>\n<p style=\"text-align: start;\">That means the 49ers won\u2019t have to go up against a terrifying defensive front anchored by Donald and Myles Garrett, added during the offseason.<\/p>\n<p style=\"text-align: start;\">Big question marks are whether 49ers stars Nick Bosa and George Kittle get in there. Bosa, coming back from a torn ACL, is expected to play. How much is anyone\u2019s guess. Kittle is attempting a remarkable quick return from a torn Achilles.<\/p>\n<p style=\"text-align: start;\">Rams\u2019 quarterback Matthew Stafford won the NFL MVP last year, throwing for 4,707 passing yards and 46 touchdown passes. Can the Rams\u2019 offence keep rolling, with Puka Nacua and Davante Adams in there?<\/p>\n<p style=\"text-align: start;\">On the San Francisco side, the 49ers rebuilt their receiving core, with veteran Mike Evans giving Brock Purdy a big, red zone presence.<\/p>\n<p style=\"text-align: start;\">Key matchups? Start with Garrett versus Trent Williams, the elite tackle on the San Francisco side of the ball, which in the end will determine whether Purdy can run the 49ers\u2019 full passing offence. With Donald out, the 49ers can focus more on Garrett, but the Rams can also move Garrett around. That favours the Rams and the under, if Los Angeles can pull that off.<\/p>\n<p style=\"text-align: start;\">Another factor is Bosa\u2019s true health. Coming back from an ACL injury, if Bosa can somehow hurry Stafford, that will impact how well Stafford gets the ball out to Nacua and Adams.<\/p>\n<p><span class=\"pen-black\" style=\"color: rgb(0, 0, 0);\">That would push the game over 48.5.<\/span><\/p>\n"},{"acf_fc_layout":"editor_block","content":"<h2>Rams vs 49ers Odds<\/h2>\n"},{"acf_fc_layout":"editor_block","content":"<p>In <a target=\"_blank\" class=\"editor-link\" href=\"https:\/\/betway.com\/g\/en\/sports\/grp\/american-football\/usa\/nfl\"><u>NFL betting<\/u><\/a> at Betway, the Rams are -300 moneyline favourites, with the 49ers at +120. Los Angeles is a 3.5-point favourite at -110, while San Francisco is +3.5 at -110. The total is 48.5 points, with the over and under both priced at -110.<\/p>\n<p style=\"text-align: start;\">So, do you pay the Rams\u2019 steep moneyline price or take them to cover 3.5 points at better odds?<\/p>\n"},{"acf_fc_layout":"editor_block","content":"<h2>Rams vs 49ers Betting Trends<\/h2>\n"},{"acf_fc_layout":"editor_block","content":"<p>Last season, both games between these two teams went over the total, and the road team won outright both times \u2013 San Francisco won at SoFi Stadium before Los Angeles won at Levi\u2019s Stadium.<\/p>\n"},{"acf_fc_layout":"editor_block","content":"<\/p>\n<p><span class=\"pen-black\" style=\"color: rgb(0, 0, 0);\">The underdog delivered a big upset in the first meeting last season, with Mac Jones throwing for 342 yards in the place of Purdy as the 49ers won, a testament to Kyle Shanahan\u2019s offensive system.<\/span><\/p>\n"},{"acf_fc_layout":"editor_block","content":"<h2>Rams vs 49ers Betting Picks<\/h2>\n"},{"acf_fc_layout":"editor_block","content":"<p>For my <a target=\"_blank\" class=\"editor-link\" href=\"https:\/\/blog.betway.com\/ca\/football\/nfl\/\"><u>NFL picks<\/u><\/a>, I hear people talking about an advantage the 49ers have: travelling to Australia on Sept. 4 and acclimating, while the Rams fly in the night before kickoff.<\/p>\n<p style=\"text-align: start;\">I\u2019ll take the 49ers +3.5; that\u2019s my main lean. The Rams will be without Donald as well, and both teams are extremely well-coached. The Rams are an understandable moneyline favourite, but the 49ers have a serious shot to keep it within a field with no Donald in there.<\/p>\n<p style=\"text-align: start;\">The under 48.5 is another strong play, considering Week 1 rust, which everyone is dealing with, plus a 15-hour flight around the world to play the game. I am still trying to figure out why the NFL is going there.<\/p>\n<p style=\"text-align: start;\">However, two familiar defences are going head-to-head in a possession-style game. That\u2019s what I see.<\/p>\n<p style=\"text-align: start;\">Plus, Christian McCaffrey anytime touchdown scorer, -140 at Betway. The 49ers running back is appealing at that number because he gives you two ways to cash a wager \u2013 he is San Francisco\u2019s primary goal-line runner and one of Purdy\u2019s most trusted receivers.<\/p>\n<p style=\"text-align: start;\">Last season, he hauled in 102 passes for 924 yards and seven touchdowns. On the ground, he ran for 10 more and 1,202 yards.<\/p>\n<p style=\"text-align: start;\">Who knows about the workload for Kittle, coming back from an Achilles injury, so McCaffrey should be the focal point for Shanahan\u2019s red zone offence.<\/p>\n"},{"acf_fc_layout":"editor_block","content":"<h2>Rams vs 49ers Same Game Parlay Picks<\/h2>\n"},{"acf_fc_layout":"editor_block","content":"<p>A few I am looking at: Rams moneyline plus over 48.5 (+150). I can get some money on the Rams to win without requiring them to cover 3.5 points. The over cashed in both meetings last season, as I said.<\/p>\n<p style=\"text-align: start;\">Working in a player prop: McCaffrey anytime touchdown, which I really like, and 49ers +3.5, at +180 at Betway.<\/p>\n"}]},"_links":{"self":[{"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/posts\/120425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/comments?post=120425"}],"version-history":[{"count":1,"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/posts\/120425\/revisions"}],"predecessor-version":[{"id":120426,"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/posts\/120425\/revisions\/120426"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/media\/120397"}],"wp:attachment":[{"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/media?parent=120425"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/categories?post=120425"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.betway.com\/ca\/wp-json\/wp\/v2\/tags?post=120425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}